منابع مشابه
Endothelial cell junctions
In the course of a freeze-cleave study on intercellular junctions in the regenerating rat liver, we observed an unusual array of intramembranous particles located in regions of contact between endothelial cells lining the hepatic sinusoids. These arrays were characterized by an accumulation of particles which resembled a zonula occludens in their linear deployment but differed in that the conta...
متن کاملDynamic Regulation of Vascular Permeability by Vascular Endothelial Cadherin-Mediated Endothelial Cell-Cell Junctions.
Endothelial cells lining blood vessels regulate vascular barrier function, which controls the passage of plasma proteins and circulating cells across the endothelium. In most normal adult tissues, endothelial cells preserve basal vascular permeability at a low level, while they increase permeability in response to inflammation. Therefore, vascular permeability is tightly controlled by a number ...
متن کاملADAM9 is present at endothelial cell - cell junctions and regulates monocyte – endothelial transmigration
We have found that A Disintegrin And Metalloproteinase-9 (ADAM9) localises to cell-cell junctions with VE-Cadherin in confluent endothelial monolayers. Co-cultures of cells separately transfected with ADAM9-EGFP or ADAM9-HA showed expression is required in two adjacent cells for localisation to cell-cell junctions suggesting the ADAM9 ectodomain may self-associate. A direct interaction between ...
متن کاملCaveolin-1 opens endothelial cell junctions by targeting catenins.
AIMS A fundamental phenomenon in inflammation is the loss of endothelial barrier function, in which the opening of endothelial cell junctions plays a central role. However, the molecular mechanisms that ultimately open the cell junctions are largely unknown. METHODS AND RESULTS Impedance spectroscopy, biochemistry, and morphology were used to investigate the role of caveolin-1 in the regulati...
متن کاملEndothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability
UNLABELLED BACKGROUND Cellular senescence is associated with cellular dysfunction and has been shown to occur in vivo in age-related cardiovascular diseases such as atherosclerosis. Atherogenesis is accompanied by intimal accumulation of LDL and increased extravasation of monocytes towards accumulated and oxidized LDL, suggesting an affected barrier function of vascular endothelial cells. Ou...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1975
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.66.1.200